With the discovery that the unconscious mind plays a key role in the placebo effect, researchers have identified a novel mechanism that helps explain the power of placebos and nocebos.
Much of medicine is based on what is considered the strongest possible evidence: The placebo-controlled trial. A paper published in the October 19 issue of Annals of Internal Medicine — entitled “What’s In Placebos: Who Knows?” calls into question this foundation upon which much of medicine rests, by showing that there is no standard behind the standard — no standard for the placebo.
Researchers are just starting to appreciate the power that the mind can have over the body, says Tor Wager, an assistant professor of psychology at Columbia University.
“An emerging idea right now is that belief in a placebo taps into processes in your brain that produce physical results that really shape how your body responds to things,” he says. “The brain has much more control over the body than we can voluntarily exert.”
As an example of this, Wager points to the body’s response to perceived threats.
“Say it’s late at night and everything is quiet and then suddenly you see someone outside, near a window,” he explains. “Your body starts to respond. Your pupils dilate. Your heart rate goes up. You start to sweat.”
The belief that something threatening is out there produces a host of physical responses that you have little control over. If you were told to calm down and turn off these sensations, you couldn’t, Wager says. “But if the belief changes — say, it turns out that it’s just your husband coming home — the physical response changes.”
The question, now, is how to tap into these powerful, unconscious responses, Wager says.
The placebo effect is a consciousness event, and more specifically an event in which consciousness and matter interact to change or transform a disease structure into a healing process or flow. At the level of reality at which this event takes place, it is not even possible to say that it is an interaction. This is a level at which consciousness-matter, or as it is more popularly known, mind-body, are not different but are a ‘stuff’, for want of a better word, which is not committed to either condition, yet is both.
It is, in other words, a level of quantum reality. (Quantum reality describes a reality in which something, for example light, can display properties of being both matter and pure energy as waveform.) The laws of quantum mechanics apply rather than the linear-cause effect laws of more conventional science, (including medical science). Sudden changes in state, or quantum shifts, occur instantaneously. It is a reality in which all is interconnected and uncertainty reigns. We are part of natural process, influencing it and being influenced by it at subtle levels where structure is only a passing creation of continuing evolution. True natural healing takes place at this quantum level where mind and body are the same, transformation is the essence of reality, and reality is created from infinite potential.
Described in the Sept. 10 on-line issue of the Proceedings of the National Academy of Sciences (PNAS), the new findings demonstrate that the placebo effect can be activated outside of conscious awareness, and provide an explanation for how patients can show clinical improvement even when they receive treatments devoid of active ingredients or of known therapeutic efficacy.
“In this study, we used a novel experimental design and found that placebo and nocebo [negative placebo] effects rely on brain mechanisms that are not dependent on cognitive awareness,” explains first author Karin Jensen, PhD, of the Department of Psychiatry and the Martinos Center for Biomedical Imaging at Massachusetts General Hospital (MGH) and the Program in Placebo Studies (PiPS) at Beth Israel Deaconess Medical Center/Harvard Medical School. “A person can have a placebo or nocebo response even if he or she is unaware of any suggestion of improvement or anticipation of getting worse.”
It has long been believed that placebo responses are related to conscious beliefs or thoughts and that when given an inert pill or therapy, patients get better because they have the expectation that they will get better, or in the case of nocebos, get worse because they anticipate that they will get worse.
However, more recently, scientists have recognized that humans learn to expect either reward or threat quickly and automatically without needing to consciously register the idea in their brains. As the authors write, neuroimaging studies of the human brain have suggested that certain structures, such as the striatum and the amygdala, can process incoming stimuli before they reach conscious awareness, and, as a result, may mediate non-conscious effects on human cognition and behavior.
The scientists set out to determine whether placebo and nocebo responses might be activated outside of a person’s conscious awareness, even if he or she has no expectation of either improving or declining.
Jensen, together with the study’s senior author Jian Kong, MD, also of MGH and the PiPS, studied 40 healthy volunteers (24 female; 16 male, median age 23). Two experiments were conducted: In the first, researchers administered heat stimulation to participants’ arms while simultaneously showing them images of male human faces on a computer screen. The first face was associated with low pain stimulations and the second image with high pain. Patients were then asked to rate their experience of pain on a scale of 0 to 100, 0 being no pain and 100 being the worst imaginable pain, but without the patient’s knowledge that all heat stimulations would have the same moderate heat intensity. As predicted, the pain ratings correlated with the previously learned associations, with a pain rating of 19 when the subjects saw the low pain face while the high pain face resulted in subjects’ mean reports of 53 on the pain scale (nocebo effect).
Then, in the second experiment, the participants were administered the same levels of thermal heat stimulation. Once again, the facial images were projected on the computer screen — but this time, they flashed by so quickly that subjects could not consciously recognize them. The participants once again rated their pain, and despite a lack of consciously recognizable cues, the participants reported a mean pain rating of 25 in response to the low pain face (placebo effect) and a mean pain rating of 44 in response to the high pain face (nocebo response) even though they did not consciously recognize the faces on the screen.
“Such a mechanism would generally be expected to be more automatic and fundamental to our behavior compared to deliberate judgments and expectations,” explains Kong. “Most important, this study provides a unique model that allows us to further investigate placebo and nocebo mechanisms by using tools such as neuroimaging.”
As PiPS Director and study coauthor Ted Kaptchuk notes, “It’s not what patients think will happen [that influences outcomes] it’s what the nonconscious mind anticipates despite any conscious thoughts. This mechanism is automatic, fast and powerful, and does not depend on deliberation and judgment. These findings open an entirely new door towards understanding placebos and the ritual of medicine.”
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